After their wedding in 1900, Anna Louise Neumeyer moved to Munich with her husband Karl Alexander Neumeyer. The couple had two sons. In 1912, the family moved into their own house at Königinstraße 35a. While Dr. Jur. Karl Neumeyer taught as a private lecturer at the Faculty of Law, Anna Neumeyer turned her house into an important meeting place for liberal Munich residents. Her friends included many well-known personalities, such as women's rights activist Marianne Weber and her husband, sociologist Max Weber.
Anna Neumeyer had joined the ‘Verein für Fraueninteressen’ (Association for Women's Interests) founded by Anita Augspurg as early as 1901, and was a member of the association's board from 1917 to 1928. Anna Neumeyer also headed the women's group of the German Democratic Party until 1928. Dr. jur. Karl Neumeyer took over as director of the Institute for Comparative Law in 1926, having previously become an associate professor. In 1931, the Faculty of Law elected Prof. Dr. jur. Karl Neumeyer as dean.
After the Nazis seized power, Anna and Karl Neumeyer entered a period of repression, exclusion and disenfranchisement. Prof. Dr. jur. Karl Neumeyer was forced into retirement and was no longer allowed to enter libraries. Nevertheless, Anna and Karl Neumeyer decided against emigrating. Anna Neumeyer wrote: ‘It's not possible without money. You have to maintain your lifestyle, not become some supplicant in your old age just for the sake of staying alive.’ When they learned in July 1941 that they would have to leave their house and that their property, including their library, would be auctioned off, Anna and Karl Neumeyer committed suicide together in their house at Königinstraße 35a.